Product Name	Tetranectin
Chinese Name	四连接素TN抗体
Alias	C type lectin domain family 3 member B; C-type lectin domain family 3 member B; Clec3b; Plasminogen kringle 4 binding protein; Plasminogen kringle 4-binding protein; TETN_HUMAN; Tetranectin; TN; TNA.
Research Area	Tumour  Cardiovascular  Cell biology  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22, 80kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Tetranectin/CLEC3B/TNA: 51-150/202
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Function: Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Subunit: Homotrimer. Subcellular Location: Secreted. Tissue Specificity: Found in plasma. Similarity: Contains 1 C-type lectin domain. SWISS: P05452 Gene ID: 7123 Database links: Entrez Gene: 7123 Human Entrez Gene: 21922 Mouse Entrez Gene: 316099 Rat Omim: 187520 Human SwissProt: P05452 Human SwissProt: P43025 Mouse Unigene: 476092 Human Unigene: 34588 Mouse 四连接素(Tetranectin， TN)是一种血纤维蛋白溶酶原Binding protein，可出现在血浆及Extracellular matrix(extracellular matrix， ECM)。TN除了它的血纤维蛋白溶酶原Binding protein特性外，还能与肝磷脂、载Lipoprotein(a)，组织纤维蛋白溶酶原激活剂，肝细胞生长因子及血管他丁。TN的表达可在各种内分泌组织、endothelial cells、及间质细胞检测到，其中间质细胞包括成纤维细胞、单核细胞和中性粒细胞。血清TN水平的下降可见于创伤后或急性心肌梗塞后，类风湿性关节炎及恶性Tumour等。虽然TN的确切生物学功能未被证实，一些实验证据表明TN在组织的修复重建中起重要的作用。TN可以增加组织型纤维蛋白溶酶原激活剂催化激活纤维蛋白溶酶原以多聚赖氨酸的催化激活作用。因为活化的纤维蛋白溶酶原被公认在Extracellular matrix的退变中起重要作用。

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