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Product Name SIPA1 Chinese Name 信号诱导增殖相关蛋白1抗体 Alias GTPase activating protein Spa 1; GTPase-activating protein Spa-1; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1. Research Area Cell biology immunology Developmental biology Signal transduction Stem cells Cyclin Epigenetics G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 112kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SIPA1: 351-450/1042 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state. Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Function:
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
Subcellular Location:
Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.
Tissue Specificity:
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Similarity:
Contains 1 PDZ (DHR) domain.
Contains 1 Rap-GAP domain.
SWISS:
Q96FS4
Gene ID:
6494
Database links:Entrez Gene: 6494 Human
Entrez Gene: 20469 Mouse
Omim: 602180 Human
SwissProt: Q96FS4 Human
SwissProt: P46062 Mouse
Unigene: 530477 Human
Unigene: 3072 Mouse
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