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Product Name QSOX1 Chinese Name 巯基氧化酶1抗体 Alias QSOX1_HUMAN; Sulfhydryl oxidase 1; QSCN6; EC:1.8.3.2; hQSOX; Quiescin Q6; UNQ2520/PRO6013; quiescin sulfhydryl oxidase 1; Q6; Research Area Tumour Cell biology Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 80kDa Cellular localization cytoplasmic The cell membrane Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human QSOX1: 244-350/747 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.
Subunit:
Monomer.
Subcellular Location:
Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.
Similarity:
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
Contains 1 ERV/ALR sulfhydryl oxidase domain.
Contains 1 thioredoxin domain.
SWISS:
O00391
Gene ID:
5768
Database links:Entrez Gene: 5768 Human
Entrez Gene: 104009 Mouse
Omim: 603120 Human
SwissProt: O00391 Human
SwissProt: Q8BND5 Mouse
Unigene: 518374 Human
Unigene: 719176 Human
Unigene: 27035 Mouse
Unigene: 44920 Rat
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