Product Name	MDM2BP
Chinese Name	双微体2癌基因Binding protein抗体
Alias	MDM 2 binding protein; MDM 2 BP; MDM2 (mouse double minute 2) binding protein 104kD; MDM2 (mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; MDM2BP; Mouse double minute 2 homolog binding protein; MTBP_HUMAN.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Cyclin  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	102kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MTBP/MDM2BP: 821-904/904
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. Function: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Subunit: Interacts with MDM2. Similarity: Belongs to the MTBP family. SWISS: Q96DY7 Gene ID: 27085 Database links: Entrez Gene: 27085 Human Entrez Gene: 105837 Mouse Omim: 605927 Human SwissProt: Q96DY7 Human SwissProt: Q80VU3 Mouse SwissProt: Q8BJS8 Mouse SwissProt: Q8BTU9 Mouse SwissProt: Q8BTW0 Mouse SwissProt: Q9ER61 Mouse Unigene: 186433 Human Unigene: 46701 Human Unigene: 61901 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MDM2BP) Polyclonal Antibody, Unconjugated (SL6388R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MDM2BP) Polyclonal Antibody, Unconjugated (SL6388R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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