Product Name	ERCC6L
Chinese Name	发育相关蛋白ERCC6L/乙醇致畸因子抗体
Alias	ATP dependent helicase ERCC6 like; DNA excision repair protein ERCC 6 like; ERCC 6L; ERCC6L; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105; MGC131695; PICH; Plk1 interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ HCC 15; ERC6L_HUMAN.
literatures	Specific References  (1)     |     SL6380R has been referenced in 1 publications. [IF=3.15] Han Chen. et al. ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K/AKT and NF-κB signaling pathway. Bmc Cancer. 2020 Dec;20(1):1-10  WB ;  Human.   PubMed:32891122
Research Area	Cell biology  Developmental biology  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	141kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ERCC6L: 301-400/1250
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ERCC6L belongs to the SNF2 ATPase family and acts as an essential component of the spindle assembly checkpoint. It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. It acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L may also play a role in the teratogenic action of alcohol. Function: DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Subunit: Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Subcellular Location: Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. Post-translational modifications: Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. Similarity: Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 2 TPR repeats. SWISS: Q2NKX8 Gene ID: 54821 Database links: Entrez Gene: 54821 Human Omim: 300687 Human SwissProt: Q2NKX8 Human Unigene: 47558 Human

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