Product Name	ALOX15B
Chinese Name	花生四烯酸15脂氧合酶2抗体
Alias	15 LO 2; 15 LOX 2; 15-lipoxygenase 2; 15-LOX-2; 15-LOX-B; ALOX15B; Arachidonate 15 lipoxygenase second type; Arachidonate 15 lipoxygenase type II; Arachidonate 15-lipoxygenase B; Arachidonate 15-lipoxygenase type II; LX15B_HUMAN; ALOX8_MOUSE; Arachidonate 8S-lipoxygenase; 8-LOX; 8S-LOX; 15-lipoxygenase 2; Arachidonate 15-lipoxygenase B; 15-LOX-B.
literatures	Specific References  (1)     |     SL6335R has been referenced in 1 publications. [IF=5.502] Xurui Li. et al. p53 activates the lipoxygenase activity of ALOX15B via inhibiting SLC7A11 to induce ferroptosis in bladder cancer cells. LAB INVEST. 2023 Jan;:100058  IHC ;  Human.   PubMed:10.1016/j.labinv.2022.100058
Research Area	Tumour  Cardiovascular  Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	74kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ALOX15B/15 Lipoxygenase 2: 13-110/676
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Tissue specificity: Expressed in hair, prostate, lung and cornea. Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in hair, prostate, lung and cornea. Similarity: Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain. SWISS: O15296 Gene ID: 247 Database links: Entrez Gene: 247 Human Entrez Gene: 11688 Mouse Entrez Gene: 266604 Rat Omim: 603697 Human SwissProt: O15296 Human SwissProt: O35936 Mouse SwissProt: Q5NCF6 Mouse SwissProt: Q5NCF7 Mouse SwissProt: Q8K4F2 Rat Unigene: 111256 Human Unigene: 289672 Mouse Unigene: 86437 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALOX15B ) Polyclonal Antibody, Unconjugated (SL6335R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (mouse ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALOX15B ) Polyclonal Antibody, Unconjugated (SL6335R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat ovary tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALOX15B) Polyclonal Antibody, Unconjugated (SL6335R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining

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