Product Name	RNF47
Chinese Name	Ring finger protein47抗体
Alias	BAR; Bfar; BFAR_HUMAN; Bifunctional apoptosis inhibitor; Bifunctional apoptosis regulator; RING finger protein 47; RNF47.
Research Area	Cell biology  immunology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Bifunctional apoptosis inhibitor: 301-400/450
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Two converging apoptotic pathways, which are initiated either through the activation of death domain (DD) receptors by an extrinsic pathway or by an intrinsic pathway in the mitochondria, mediate the activation and progression of apoptosis within the cell. Both these pathways lead to the activation of the Serine proteinase cascade (caspases) and to cleavage of these pro-caspases. A novel protein, BAR, for bifunctional apoptosis regulator, contains domains that enable it to interact with components of both major apoptosis pathways, where it negatively regulates apoptotic signaling. Like the other anti-apoptosis proteins Bap31 and FLIP, BAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. In addition, BAR contains a domain that also enables it to interact with the mitochondrial Bcl-2 family of proteins. The presence of these various RING, SAM, DED and TM domains suggests that BAR may serve as a scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. Subunit: Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen. Similarity: Interacts with CASP8, Contains 1 RING-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. SWISS: Q9NZS9 Gene ID: 51283 Database links: Entrez Gene: 51283 Human Entrez Gene: 67118 Mouse Entrez Gene: 304709 Rat SwissProt: Q9NZS9 Human SwissProt: Q8R079 Mouse SwissProt: Q5PQN2 Rat Unigene: 435556 Human Unigene: 223689 Mouse Unigene: 159939 Rat Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Tissue specificity: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle.

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