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Product Name GCMA Chinese Name 绒毛膜特异性转录因子GCMa抗体 Alias Chorion specific transcription factor GCMa; Chorion-specific transcription factor GCMa; GCM 1; GCM A; GCM motif protein 1; Gcm1; GCM1_HUMAN; Gcm1rs1; GCMA; Gcmrs2; Glial cells missing homolog 1; Glial cells missing homolog a; Glide; hGCMa. literatures Specific References (1) | SL6306R has been referenced in 1 publications.[IF=4.545] Zhe Li. et al. SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth. Biomed Pharmacother. 2021 Jan;133:111011 WB ; Mouse.Research Area Cell biology immunology Developmental biology Signal transduction Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GCMA/GCM1: 121-220/436 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008].
Function:
Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.
Subcellular Location:
Nucleus.
Tissue Specificity:
Placenta specific.
Similarity:
Contains 1 GCM DNA-binding domain.
SWISS:
Q9NP62
Gene ID:
8521
Database links:
UniProtKB/Swiss-Prot: Q9NP62.1
Product Picture Paraformaldehyde-fixed, paraffin embedded (Rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GCMA) Polyclonal Antibody, Unconjugated (SL6306R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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