Product Name	EMP2
Chinese Name	epithelial cells膜蛋白2抗体
Alias	EMP-2; EMP2; EMP2_HUMAN; Epithelial membrane protein 2; Protein XMP.
literatures	Specific References  (2)     |     SL6264R has been referenced in 2 publications. [IF=7.273] Torella D et al. MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus.(2018) Diabetes. Sep 26  IF ;  Rat.   PubMed:30257973 [IF=3.117] Pan, Jian. et al. miR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization. 2021 Sep 08  WB ;  human,rat.   PubMed:34495369
Research Area	Tumour  Developmental biology  Signal transduction  Kinases and Phosphatases  Cell adhesion molecule  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19/24kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EMP2: 65-167/167
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	EMP-2 is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the PMP-22/EMP/MP20 family. SWISS: P54851 Gene ID: 2013 Database links: Entrez Gene: 2013 Human Entrez Gene: 13731 Mouse Omim: 602334 Human SwissProt: P54851 Human SwissProt: O88662 Mouse Unigene: 531561 Human Unigene: 246009 Mouse

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