Product Name	NEK3
Chinese Name	丝氨酸/苏氨酸蛋白激酶Nek3抗体
Alias	HSPK 36; HSPK36; HSPK-36; NEK3; NEK 3; NEK-3; NEK3_HUMAN; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a) related kinase 3; NimA related protein kinase 3; NimA-related protein kinase 3; Serine/threonine protein kinase Nek3; Serine/threonine-protein kinase Nek3.
Research Area	Tumour  Cell biology  immunology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	58kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NEK3: 165-265/506
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar2009]. Function: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. Subunit: Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent. Subcellular Location: Cytoplasm (By similarity). Cell projection, axon (By similarity). Tissue Specificity: Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain. Post-translational modifications: Phosphorylation at Thr-479 regulates its catalytic activity (By similarity). Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 protein kinase domain. SWISS: P51956 Gene ID: 4752 Database links: Entrez Gene: 4752 Human Entrez Gene: 23954 Mouse Entrez Gene: 306576 Rat Omim: 604044 Human SwissProt: P51956 Human SwissProt: Q9R0A5 Mouse Unigene: 409989 Human Unigene: 41413 Mouse Unigene: 45730 Rat
Product Picture	Sample: Small intestine (Mouse) Lysate at 40 ug Large intestine (Mouse) Lysate at 40 ug Urinary bladder (Mouse) Lysate at 40 ug Stomach (Mouse) Lysate at 40 ug Primary: Anti-NEK3 (SL6261R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD

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