Product Name	MAGEF1
Chinese Name	黑色素瘤抗原F蛋白家族1抗体
Alias	MAGE F1 antigen; MAGEF 1; Melanoma antigen family F, 1; Melanoma associated antigen F1; MGC19617; MAGF1_HUMAN.
Research Area	Tumour  Cell biology  immunology  Chromatin and nuclear signals  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Dog, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MAGEF1: 55-150/307
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MAGEF1 is a member of the MAGE (melanoma antigen gene) superfamily. Most known members of the MAGE superfamily are expressed in tumors, testis and fetal tissues, which has been described as a cancer/testis or "CT" expression pattern. MAGEF1, however, is expressed in all adult and fetal tissues tested, as well as in many tumor types including ovarian, breast, cervical, melanoma and leukemia. The coding region of MAGE-F1 is contained within a single exon and includes a microsatellite repeat. Several MAGE genes are ubiquitously expressed suggesting a role for MAGE encoded proteins in normal cell physiology. Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Subunit: Interacts with LNX1, TRIM27 and NSMCE1. Tissue Specificity: Ubiquitous. Similarity: Contains 1 MAGE domain. SWISS: Q9HAY2 Gene ID: 64110 Database links: Entrez Gene: 64110 Human Omim: 609267 Human SwissProt: Q9HAY2 Human Unigene: 306123 Human

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