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Product Name RDH11 Chinese Name 视黄醇脱氢酶11/丙型肝炎病毒核心蛋白抗体 Alias CGI 82; RALR1; Androgen regulated short chain dehydrogenase/reductase 1; ARSDR1; HCBP12; HCV core binding protein; HCV core binding protein HCBP12; MDT1; Prostate short chain dehydrogenase/reductase 1; PSDR1; Retinal reductase 1; retinol dehydrogenase 11 (all trans/9 cis/11 cis); Retinol dehydrogenase 11; SCALD; SDR7C1; Short chain dehydrogenase/reductase family 7C, member 1; RDH11_HUMAN. literatures Specific References (1) | SL6214R has been referenced in 1 publications.[IF=4.366] Jae Yeon Kim. et al. PEDF-Mediated Mitophagy Triggers the Visual Cycle by Enhancing Mitochondrial Functions in a H2O2-Injured Rat Model. Cells-Basel. 2021 May;10(5):1117 IHC ; Rat.Research Area Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 35kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RDH11: 31-130/318 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity.
Function:
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity:
Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.
Post-translational modifications:
Not glycosylated.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SWISS:
Q8TC12
Gene ID:
51109
Database links:Entrez Gene: 51109 Human
Omim: 607849 Human
SwissProt: Q8TC12 Human
Unigene: 226007 Human
Unigene: 719925 Human
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