Product Name	Estrogen Related Receptor beta
Chinese Name	雌激素相关受体β抗体
Alias	Err 2; ERR b; ERR B2; ERR beta 2; ERR beta; Err2; ERRB 2; ERRb; ERRB2; ERRbeta 2; ERRbeta; ESR L2; ESRL 2; ESRL2; ESRRB; Estrogen receptor like 2; Estrogen receptor related 2; Estrrb; Nr3b2; Nuclear receptor ERRB2; Orphan nuclear receptor; Steroid hormone receptor ERR 2; Steroid hormone receptor ERR2; ERR2_HUMAN.
Research Area	Tumour  Cell biology  Developmental biology  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Estrogen Related Receptor beta: 131-230/508
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Estrogen related receptor beta, a NR3 Steroid Receptor, has been shown to affect early placental development. Also it can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). It binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). Estrogen related receptor beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. Expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries. The ligand for the receptor is PPARgamma coactivator 1 (PGC-1) beta. Function: Nuclear receptor that binds DNA as monomer. Subunit: Monomer. Subcellular Location: Nuclear DISEASE: Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:608565]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: O95718 Gene ID: 2103 Database links: Entrez Gene: 490798 Dog Entrez Gene: 2103 Human Entrez Gene: 26380 Mouse Entrez Gene: 299210 Rat Omim: 602167 Human SwissProt: O95718 Human SwissProt: Q61539 Mouse SwissProt: P11475 Rat Unigene: 337489 Human Unigene: 435845 Human Unigene: 235550 Mouse Unigene: 104984 Rat

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