TEL: +86 571 56623320 EMAIL: [email protected]
Product Name CIKS/TRAF3IP2 Chinese Name 核因子NFκB激活蛋白1抗体 Alias Act 1; ACT1; Activator of cAMP responsive element modulator (CREM) in testis; Adapter protein CIKS; C6ORF4; C6ORF5; C6ORF6; Chromosome 6 Open Reading Frame 4; Chromosome 6 Open Reading Frame 5; Chromosome 6 Open Reading Frame 6; CIKS; CIKS_HUMAN; Connection to IKK and SAPK / JNK; Connection to IKK and SAPK/JNK; Nuclear Factor Kappa B Activator 1; Nuclear factor NF kappa B activator 1; Nuclear factor NF-kappa-B activator 1; TRAF3 interacting protein 2; TRAF3-interacting protein 2; TRAF3IP2. literatures Specific References (2) | SL6202R has been referenced in 2 publications.[IF=5.201] Janak L. Pathak. et al. Downregulation of Macrophage-Specific Act-1 Intensifies Periodontitis and Alveolar Bone Loss Possibly via TNF/NF-κB Signaling. Front Cell Dev Biol. 2021; 9: 628139 IHC ; Mouse.[IF=4.259] Wu Z et al. Co-infection of Mycoplasma gallisepticum and Escherichia coli Triggers Inflammatory Injury Involving the IL-17 Signaling Pathway. Front Microbiol. 2019 Nov 15;10:2615. WB ; Chicken.Research Area Chromatin and nuclear signals Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 63kDa Cellular localization The nucleus cytoplasmic Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TRAF3IP2: 501-574/574 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
Subunit:
Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.
Tissue Specificity:
Widely expressed.
DISEASE:
Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13) [MIM:614070]. PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Similarity:
Contains 1 SEFIR domain.
SWISS:
O43734
Gene ID:
10758
Database links:Entrez Gene: 10758 Human
Entrez Gene: 103213 Mouse
Omim: 607043 Human
SwissProt: O43734 Human
Unigene: 561514 Human
Unigene: 436686 Mouse
Unigene: 9031 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CIKS) Polyclonal Antibody, Unconjugated (SL6202R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Scan Wechat Qrcode
Scan Whatsapp Qrcode