Product Name	Renin
Chinese Name	肾素/血管紧张素形成酶Ren1抗体
Alias	Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; HNFJ2; REN; Renin1; Renin-1; Renin 1; Ren1; RENI_HUMAN; Renin; Renin precursor renal.
literatures	Specific References  (9)     |     SL6184R has been referenced in 9 publications. [IF=5.11] Wanka, Heike, et al. "Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions." Journal of Molecular Medicine(2015): 1-9.  WB ;  Rat.   PubMed:26256830 [IF=5.1] Wu, Ka, et al. "Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury." Cellular Physiology and Biochemistry 43.4 (2017): 1-1.  IHC-P ;  Mouse.   PubMed:29035890 [IF=3.598] Xu X et al. Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers. Biofactors. 2019 May 23.  IHC-P ;  Mouse.   PubMed:31120577 [IF=3.448] Chen ZZ et al. Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. Life Sci. 2019 Nov 20;240:117085.  IHC-P&WB ;  Rat.   PubMed:31759042 [IF=2.96] Jiamei Yao. et al. Comparative transcriptomic analysis revealed novel potential therapeutic targets of traditional Chinese medicine (Pinggan-Qianyang decoction) on vascular remodeling in spontaneously hypertensive rats. Chin Med-Uk. 2021 Dec;16(1):1-17  WB ;  Rat.   PubMed:33568194 [IF=2.81] Soto et al. Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. (2017) PLoS.One. 12:e0183314  ELISA ;  Rat.   PubMed:28820906 [IF=1.92] Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192.  WB ;  Dog.   PubMed:27724864 [IF=1.785] Yongli Zhao. et al. Calcilytic NPS2143 promotes proliferation and inhibits apoptosis of spontaneously hypertensive rat vascular smooth muscle cells via activation of the renin‑angiotensin system. Exp Ther Med. 2020 Aug;20(2):818-829  WB,IF ;  Rat.   PubMed:32742325 [IF=1.41] R Sun et al. Calcimimetic R568 reduced the blood pressure and improved aortic remodeling in spontaneously hypertensive rats by inhibiting local renin‑angiotensin system activity.(2018),Experimental and Therapeutic Medicine. 16: 4089-4099  WB ;  Rat.   PubMed:10.3892/etm.2018.6734
Research Area	Tumour  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Dog, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Renin: 331-406/406
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]. Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Subunit: Interacts with ATP6AP2. Subcellular Location: Secreted. Membrane. Associated to membranes via binding to ATP6AP2. DISEASE: Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. Similarity: Belongs to the peptidase A1 family. SWISS: P00797 Gene ID: 5972 Database links: Entrez Gene: 469651 Chimpanzee Entrez Gene: 5972 Human Entrez Gene: 19701 Mouse Entrez Gene: 19702 Mouse Entrez Gene: 24715 Rat Omim: 179820 Human SwissProt: P60016 Chimpanzee SwissProt: Q6DLS0 Cynomolgus Monkey SwissProt: P00797 Human SwissProt: P00796 Mouse SwissProt: P06281 Mouse SwissProt: P08424 Rat Unigene: 3210 Human Unigene: 220955 Mouse Unigene: 9831 Rat
Product Picture	Sample: Lane 1: Mouse Kidney Lysates Lane 2: Rat Kidney Lysates Primary: Anti-Renin (SL6184R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37kDa Observed band size: 37kDa

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