Product Name	HLTF
Chinese Name	解旋酶样转录因子抗体
Alias	DNA-binding protein/plasminogen activator inhibitor 1 regulator; Helicase like transcription factor; Helicase-like transcription factor; HIP116; HIP116A; HLTF 1; HLTF; HLTF_HUMAN; HLTF1; p113; RING finger protein 80; RNF80; SMARC A3; SMARCA 3; SMARCA3; SNF2-like 3; SNF2L3; Sucrose nonfermenting protein 2 like 3; Sucrose nonfermenting protein 2-like 3; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; ZBU 1; ZBU1.
literatures	Specific References  (1)     |     SL6107R has been referenced in 1 publications. [IF=8.185] Tan Ye. et al. Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis. J MOL CELL BIOL. 2023 Feb;:  IHC ;  Human.   PubMed:36822623
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	114kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HLTF.: 201-300/1009
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Function: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Subunit: Binds to SP1 and SP3 independent of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes. Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N. Subcellular Location: Nucleus. Tissue Specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Similarity: Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 RING-type zinc finger. SWISS: Q14527 Gene ID: 6596 Database links: Entrez Gene: 6596 Human Entrez Gene: 20585 Mouse Entrez Gene: 295568 Rat Omim: 603257 Human SwissProt: Q14527 Human SwissProt: Q6PCN7 Mouse Unigene: 3068 Human Unigene: 209650 Mouse Unigene: 161819 Rat

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