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Product Name RIL Chinese Name 抑癌基因PDLIM4抗体 Alias Enigma homolog; LIM domain protein; LIM protein RIL; PDLIM 4; PDLIM4; PDZ and LIM domain 4; PDZ and LIM domain protein 4; Reversion induced LIM protein; PDLI4_HUMAN. Research Area Tumour Chromatin and nuclear signals transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 35kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RIL: 251-330/330 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail RIL, also known as PDLIM4 is a putative tumor suppressor gene. RIL is transcriptionally repressed by hypermethylation in a variety of tumors including breast and prostate. The difference in methylation status of RIL between normal and cancerous tissues is being investigated as to determine the use of RIL as a potential biomarker. Two isoforms of human RIL one have been identified.
Subcellular Location:
Cytoplasmic
Similarity:
Contains 1 LIM zinc-binding domain.
Contains 1 PDZ (DHR) domain.
SWISS:
P50479
Gene ID:
8572
Database links:
Entrez Gene: 8572 Human
Entrez Gene: 30794 Mouse
Omim: 603422 Human
SwissProt: P50479 Human
SwissProt: P70271 Mouse
Unigene: 424312 Human
Unigene: 21830 Mouse
Unigene: 34221 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (human breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RIL) Polyclonal Antibody, Unconjugated (SL6093R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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