Product Name	PDGFRL
Chinese Name	血小板源性生长因子受体β样蛋白抗体
Alias	PDGF receptor beta like tumor suppressor; PGFRL_HUMAN; PDGFR-like protein; PDGRL; PRLTS.
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDGFRL: 61-150/375
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This protein is expressed in colon, lung and liver. Defects in PDGFRL are associated with colorectal cancer. Subunit: Forms a complex composed of PDGFRL, TNK2 and GRB2. Subcellular Location: Secreted (Probable). Tissue Specificity: Expressed in colon, lung and liver. DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry is involved in disease pathogenesis. Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease (PubMed:19815557). Behcet disease is a complex multiple-system disorder characterized by recurrent oral ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q15198 Gene ID: 5157 Database links: Entrez Gene: 5157 Human Entrez Gene: 68797 Mouse Entrez Gene: 515017 Cow GenBank: NP_006198.1 Human Omim: 604584 Human SwissProt: Q5BIP2 Cow SwissProt: Q15198 Human SwissProt: Q2PFX1 Monkey SwissProt: Q6PE55 Mouse Unigene: 458573 Human Unigene: 284246 Mouse

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