Product Name	NIT1
Chinese Name	腈水解酶1抗体
Alias	NIT1; NIT1_HUMAN; Nitrilase 1; Nitrilase homolog 1.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Neurobiology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NBL1: 111-210/327
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Play a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. it is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2. Function: Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). Subcellular Location: Cytoplasm. Mitochondrion. Tissue Specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Similarity: Belongs to the UPF0012 family. Contains 1 CN hydrolase domain. SWISS: Q86X76 Gene ID: 4817 Database links: Entrez Gene: 4817 Human Entrez Gene: 27045 Mouse Entrez Gene: 289222 Rat Omim: 604618 Human SwissProt: Q86X76 Human SwissProt: Q8VDK1 Mouse SwissProt: Q7TQ94 Rat Unigene: 146406 Human Unigene: 12915 Mouse Unigene: 270139 Mouse Unigene: 440362 Mouse Unigene: 64425 Rat

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