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Product Name MCC Chinese Name 大肠癌Tumour突变蛋白抗体 Alias Colorectal mutant cancer protein; MCC 1; MCC-1; MCC1; Mutated in colorectal cancers; Protein MCC; CRCM_HUMAN. Research Area Tumour Cell biology immunology TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 93kDa Cellular localization The nucleus The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MCC.: 731-829/829 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Subunit:
Interacts with SCRIB, EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation.
Subcellular Location:
Cell membrane. Nucleus. Cytoplasm.
Tissue Specificity:
Expressed in a variety of tissues.
Similarity:
Belongs to the MCC family.
SWISS:
P23508
Gene ID:
4163
Database links:Entrez Gene: 4163 Human
Entrez Gene: 328949 Mouse
Omim: 159350 Human
SwissProt: P23508 Human
Unigene: 593171 Human
Unigene: 312511 Mouse
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