Product Name	GSK3A
Chinese Name	糖原合酶激酶3α抗体
Alias	GSK3A_HUMAN; Glycogen synthase kinase-3 alpha; Glycogen synthase kinase 3 alpha; EC:2.7.11.26; Serine/threonine-protein kinase GSK3A; EC:2.7.11.1; GSK 3 alpha; GSK3alpha; GSK-3 alpha; GSK3 alpha; GSK-3alpha; GSK 3A;
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Rat, )
Applications	WB=1:500-1:1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2a/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011] SWISS: P49840 Gene ID: 2931 Database links: Entrez Gene: 2931 Human Entrez Gene: 50686 Rat SwissProt: P49840 Human SwissProt: P18265 Rat 组成性活性蛋白激酶，通过磷酸化和失活糖原合成酶（GYS1或GYS2）、CTNNB1/β连环蛋白、APC和AXIN1，在激素控制葡萄糖稳态、Wnt信号传导和转录因子及微管的调节中作为负调节因子。它的大多数底物需要启动磷酸化。通过磷酸化和抑制GYS1活性从而促进糖原合成的胰岛素调节。调节肝脏的糖原代谢，而不是肌肉。也可能通过调节转录因子的激活来介导胰岛素抵抗的发展。在Wnt信号中，调节核CTNNB1/β连环蛋白的水平和转录活性。促进淀粉样前体蛋白（APP）的加工和阿尔茨海默病APP源性淀粉样斑块的形成。可能参与胰腺β细胞复制的调控。也是建立神经元极性和轴突生长所必需的。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rat IgG H&L (HRP) Lysate: 293, U87MG Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 51 kDa Observed MW: 51 kDa Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rat IgG H&L (HRP) Lysate: Rat lung Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 51 kDa Observed MW: 51 kDa

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