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Product Name CST7 Chinese Name 半胱氨酸蛋白酶抑制剂7抗体 Alias CMAP; CST 7; CST7; Cystatin 7; Cystatin-7; Cystatin7; Cystatin like metastasis associated protein; CystatinF; Cystatin-F; Cystatin F; Leukocystatin. literatures Specific References (1) | SL6039R has been referenced in 1 publications.[IF=15.6] Zhang, L., Liu, X., Liu, D., Yu, X., Zhang, L., Zhu, J., … Liu, R. (2020). A Conditionally Releasable “Do not Eat Me” CD47 Signal Facilitates Microglia‐Targeted Drug Delivery for the Treatment of Alzheimer’s Disease. Advanced Functional Materials, 1910691. WB ; mouse.Research Area Cardiovascular Cell biology immunology Signal transduction Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 14kDa Cellular localization cytoplasmic Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Cystatin F: 21-120/145 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors.
Function:
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted. Cytoplasm.
Tissue Specificity:
Primarily expressed in peripheral blood cells and spleen.
Similarity:
Belongs to the cystatin family.
SWISS:
O76096
Gene ID:
8530
Database links:
Entrez Gene: 8530 Human
Omim: 603253 Human
SwissProt: O76096 Human
Unigene: 143212 Human
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