TEL: +86 571 56623320 EMAIL: [email protected]
Product Name CA12 Chinese Name 碳酸酐酶12抗体 Alias CA 12; CA XII; Carbonate dehydratase XII; Carbonic anhydrase 12; Carbonic anhydrase XII; Carbonic dehydratase; CAXII; Tumor antigen HOM RCC 3.1.3. literatures Specific References (1) | SL6025R has been referenced in 1 publications.[IF=3.869] Sinkemani A et al. Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic ConditionsStem Cells Int.2020 Dec 23;2020:8882549. IF ; Rat.Research Area Tumour Cell biology immunology TumourCell biologyMaker Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 37kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CA12: 241-340/354 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CA12 (Carbonic anhydrase XII) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide.
Function:
Reversible hydration of carbon dioxide.
Subunit:
Homodimer.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.
DISEASE:
Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
Similarity:
Belongs to the alpha-carbonic anhydrase family.
SWISS:
O43570
Gene ID:
771
Database links:Entrez Gene: 771 Human
Omim: 603263 Human
SwissProt: O43570 Human
Unigene: 210995 Human
Scan Wechat Qrcode