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Product Name RBBP5 Chinese Name 视网膜母细胞瘤Binding protein5抗体 Alias RBBP 5; RBQ 3; RBQ3; Retinoblastoma binding protein 5; Retinoblastoma binding protein RBQ3; Retinoblastoma binding protein5; SWD1; SWD1, Set1c WD40 repeat protein, homolog. Research Area Tumour immunology Chromatin and nuclear signals Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 59kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RBBP5: 131-230/538 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail RbBP5, retinoblastoma binding protein 5, belongs to a highly conserved subfamily of WD proteins and contains 6 WD repeats. It binds preferentially to underphosphorylated retinoblastoma protein, which is involved in the control of cell proliferation. RbBP5 is a component of the SET1 complex and of MLL containing complexes. RbBP5 is phosphorylated in response to DNA damage, probably by ATM/ATR.
Function:
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Subunit:
Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL, MLL2/ALR, MLL3 and MLL4/WBP7), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 6 WD repeats.
SWISS:
Q15291
Gene ID:
5929
Database links:Entrez Gene: 5929 Human
Entrez Gene: 213464 Mouse
Omim: 600697 Human
SwissProt: Q15291 Human
SwissProt: Q8BX09 Mouse
Unigene: 519230 Human
Unigene: 132868 Mouse
视网膜母细胞瘤Binding protein5抗体
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