TEL: +86 571 56623320 EMAIL: [email protected]
Product Name GTPBP4 Chinese Name GTPBinding protein4抗体(慢性肾功能衰竭蛋白) Alias Chronic renal failure gene protein; CRFG; G protein binding protein CRFG; GTP binding protein 4; NGB; NOG1; Nucleolar GTP binding protein 1; NOG1_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Binding protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 74kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GTPBP4/CRFG: 301-400/643 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [Entrez Gene]
Function:
Involved in the biogenesis of the 60S ribosomal subunit
Subcellular Location:
Nucleus, nucleolus.
Similarity:
Belongs to the GTP1/OBG family. NOG subfamily.
SWISS:
Q9BZE4
Gene ID:
23560
Database links:Entrez Gene: 23560 Human
Entrez Gene: 69237 Mouse
SwissProt: Q9BZE4 Human
SwissProt: Q99ME9 Mouse
Unigene: 215766 Human
Unigene: 41800 Mouse
Unigene: 96111 Rat
Scan Wechat Qrcode