Product Name	CIP2A/p90 Autoantigen
Chinese Name	蛋白磷酸酶PP2A癌抑制蛋白抗体
Alias	p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen.
Research Area	Tumour  immunology  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human p90 Autoantigen: 601-700/905
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. Subunit: Interacts with MYC. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region. Tissue Specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). SWISS: Q8TCG1 Gene ID: 57650 Database links: Entrez Gene: 57650 Human Entrez Gene: 224171 Mouse Entrez Gene: 360711 Rat Omim: 610643 Human SwissProt: Q8TCG1 Human SwissProt: Q8BWY9 Mouse SwissProt: D3ZF50 Rat Unigene: 591308 Human Unigene: 24491 Mouse

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