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Product Name KCNK9 Chinese Name TWIK相关酸敏感钾离子Channel protein9抗体 Alias KCNK 9; KCNK-9; TASK3; Potassium channel subfamily K member 9; Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K(+) channel 3; Two pore potassium channel KT3.2; Short=Two pore K(+) channel KT3.2; KCNK9_HUMAN Research Area Tumour immunology Neurobiology Channel protein Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Chicken, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 40kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KCNK9: 21-120/374 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail KCNK9 or TASK-3 (TWIK-related Acid sensitive K+ channel) is a member of the potassium channel family of proteins that contain two-pore domain and four transmembrane domains. These channels are characterized as leak K+ channels that are sensitive to changes in the extracellular pH. The physiological functions of TASK channels are largely unknown; it has been proposed that they may be involved in the regulation of breathing, aldosterone secretion and anesthetic-mediated neuronal activity. They were found to act in neurons' membrane potential and in resting K+ currents.
Function:
pH-dependent, voltage-insensitive, background potassium channel protein.
Subcellular Location:
Membrane; Multi-pass membrane protein
Tissue Specificity:
Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.
DISEASE:
Defects in KCNK9 are the cause of Birk-Barel mental retardation dysmorphism syndrome (BIBAS) [MIM:612292]. A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8)
SWISS:
Q9NPC2
Gene ID:
51305
Database links:Entrez Gene: 428382 Chicken
Entrez Gene: 51305 Human
Omim: 605874 Human
SwissProt: Q9NPC2 Human
Unigene: 493037 Human
Product Picture Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti- KCNK9 (SL5933R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 48 kD
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