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Product Name ANGPTL3 Chinese Name 血管生成素样蛋白3抗体 Alias ANG 5; ANG-5; ANG5; Angiopoietin 5; Angiopoietin like 3; Angiopoietin related protein 3; Angiopoietin-5; Angiopoietin-like protein 3; Angiopoietin-related protein 3; ANGL3_HUMAN; ANGPT5; FHBL2. Research Area Tumour Cardiovascular Cell biology immunology Signal transduction Growth factors and hormones vascular endothelial cell The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ANG5/ANGPTL3: 21-120/460 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Angiopoietin-like protein 3 (Angptl3) functions as a potent lipoprotein lipase inhibitor and is an important component of plasma triglyceride homeostasis. Angptl3 also plays a role in adipose formation and angiogenesis through its interaction with integrin ?v)beta(3). It is secreted by the liver and is functionally defined by the C-terminal fibrinogen (FBN)-like domain and an N-terminal coiled-coil domain. Angptl3 regulates circulating triglyceride levels during different nutritional states thereby mediating the feeding/fasting cycle. A deficiency of Angptl3 results in abnormally low lipid levels, and a repression of the protein may be protective against atherosclerosis. Angptl3 may also play an important role in hyperlipidemia in diabetes.
Subcellular Location:
Secreted
Tissue Specificity:
Expressed principally in liver. Weakly expressed in kidney.
Similarity:
Contains 1 fibrinogen C-terminal domain.
SWISS:
Q9Y5C1
Gene ID:
27329
Database links:Entrez Gene: 27329 Human
Entrez Gene: 30924 Mouse
Omim: 604774 Human
SwissProt: Q9Y5C1 Human
SwissProt: Q9R182 Mouse
Unigene: 209153 Human
Unigene: 28341 Mouse
Product Picture Sample:
Hepg2(Human) Cell Lysate at 30 ug
Primary: Anti-ANGPTL3 (SL5918R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 59 kD
Sample:
Lane 1: Human HL-60 cell Lysates
Lane 2: Human HepG2 cell Lysates
Lane 3: Human 293T cell Lysates
Lane 4: Human Raji cell Lysates
Lane 5: Human MOLT4 cell Lysates
Primary: Anti-ANGPTL3 (SL5918R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49kDa
Observed band size: 60kDa
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