Product Name	OS9
Chinese Name	OS-9蛋白抗体
Alias	lified in osteosarcoma 9; amplified in osteosarcoma; OS-9; Os9; OS9_HUMAN; Protein OS-9.
Research Area	Tumour  Cardiovascular  immunology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	76kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OS9: 101-200/667
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Subunit: Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts with HSP90B1 and CREB3. Subcellular Location: ndoplasmic reticulum lumen. Tissue Specificity: Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined. Post-translational modifications: Intramolecular disulfide bonds. Isoform 1 and isoform 2 are N-glycosylated. Similarity: Belongs to the OS-9 family. Contains 1 PRKCSH domain. SWISS: Q13438 Gene ID: 10956 Database links: Entrez Gene: 10956 Human Entrez Gene: 216440 Mouse Entrez Gene: 362891 Rat Omim: 609677 Human SwissProt: Q13438 Human SwissProt: Q8K2C7 Mouse SwissProt: Q5RKH6 Rat Unigene: 527861 Human Unigene: 295246 Mouse Unigene: 1579 Rat
Product Picture	Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-OS9 (SL5901CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76 kD Observed band size: 70 kD

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