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Product Name KLK15 Chinese Name 激肽释放酶15抗体 Alias ACO; ACO protease; HSRNASPH; Kallikrein 15 isoform CRA_d; Kallikrein like serine protease; Kallikrein related peptidase 15; Kallikrein15; KLK 15; KLK15; KLK15 protein; NSRNASPH; Prostin; Prostinogen. Research Area Tumour Cell biology immunology Signal transduction Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KLK15: 181-256/256 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The human tissue Kallikrein gene family encodes 15 serine proteases. All Kallikreins share structural similarities including cysteine residues, a catalytic triad of His, Asp, and Ser residues, typically five coding exons, and varied intron phases. Kallikreins are predominantly secreted as inactive zymogens prior to activation by cleavage of an N terminal peptide, and all function extracellularly. Kallikreins can be activated autocatalytically, via other Kallikreins, or additional proteases. While structurally similar, Kallikrein family members have distinct functions and have key roles in many physiological and pathological processes. Many human tissue Kallikreins also show promise as cancer biomarkers, which may facilitate earlier detection and characterization of many forms of cancer. Kallikrein 15 is one of the fifteen kallikrein subfamily members whose gene is located in a cluster on chromosome 19. Increased levels are found in prostate cancer, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. Four splice variants, each encoding a distinct isoform, have been described.
Function:
Protease whose physiological substrate is not yet known.
Subunit:
Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.
Subcellular Location:
Secreted.
Tissue Specificity:
Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.
Similarity:
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
SWISS:
Q9H2R5
Gene ID:
55554
Database links:Entrez Gene: 55554 Human
Omim: 610601 Human
SwissProt: Q9H2R5 Human
Unigene: 567535 Human
Extracellular matrix蛋白Product Picture Paraformaldehyde-fixed, paraffin embedded (rat adrenal gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KLK15) Polyclonal Antibody, Unconjugated (SL5867R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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