Product Name	FGF23
Chinese Name	成纤维细胞生长因子23抗体
Alias	ADHR; FGF-23; Fgf23; FGF 23; FGF23_HUMAN; Fibroblast growth factor 23; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 precursor; HPDR2; HYPF; Phosphatonin; PHPTC; Tumor derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor.
literatures	Specific References  (9)     |     SL5768R has been referenced in 9 publications. [IF=6.133] Zhang Hongqi. et al. Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway. CHINESE MED J-PEKING. 2023 May;:10.1097/CM9.0000000000002690  WB ;  Human.   PubMed:37192015 [IF=4.285] Stenhouse Claire. et al. Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling. Biol Reprod. 2022 Feb;:  IHC ;  Sheep（Ewe）.   PubMed:10.1093/biolre/ioac027 [IF=4.146] Cheng-Ken Tsai. et al. Low-Dose Propranolol Prevents Functional Decline in Catecholamine-Induced Acute Heart Failure in Rats. TOXICS. 2022 May;10(5):238  IHC ;  Rat.   PubMed:35622651 [IF=3.58] Andersen, Ingrid A., et al. "Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure." Nephrology Dialysis Transplantation (2015): gfv398.  IHC-F ;  Human.   PubMed:26666498 [IF=3.423] Ping Wang. et al. Iron Sucrose: A Double-Edged Sword in High Phosphate Media-Induced Vascular Calcification. 2021 Jan 13  WB ;  Rat.   PubMed:33439323 [IF=3.322] Stenhouse Claire. et al. Novel Mineral Regulatory Pathways in Ovine Pregnancy: I. Phosphate, Klotho Signaling, and Sodium Dependent Phosphate Transporters. Biol Reprod. 2021 Feb;:  IHC ;  Sheep.   PubMed:33624764 [IF=2.608] Wu W et al. Regulation of 25-hydroxyvitamin D-1-hydroxylase and 24-hydroxylase in keratinocytes by PTH and FGF23. Exp Dermatol. 2018 Nov;27(11):1201-1209.  IHC-P ;  Human.   PubMed:30066343 [IF=2.472] Bisson SK et al. High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.J Bone Miner Metab. 2018 Mar 30.  IF ;  Rat.   PubMed:29603070 [IF=1.913] Koichiro Kajiwara. et al. Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy. Bmc Nephrol. 2021 Dec;22(1):1-12  IHC ;  Mouse.   PubMed:33407253
Research Area	Tumour  Cell biology  immunology  Signal transduction  Stem cells  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Fibroblast growth factor 23: 21-120/251
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013] Function: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors. Subcellular Location: Secreted. Note=Secretion is dependent on O-glycosylation. Tissue Specificity: Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). Post-translational modifications: Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23. DISEASE: Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Similarity: Belongs to the heparin-binding growth factors family. SWISS: Q9GZV9 Gene ID: 8074 Database links: Entrez Gene: 8074 Human Omim: 605380 Human SwissProt: Q9GZV9 Human Unigene: 287370 Human
Product Picture	Sample: bone (rat)Lysate at 40 ug Primary: Anti- MRPL32 (SL5768R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27kD Observed band size: 27kD Sample: Lane 1: Bone (Rat) Lysate at 40 ug Lane 2: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-FGF23 (SL5768R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30/32 kD Observed band size: 30 kD

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Totalgoods,subtotals:￥Checkout