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Product Name MPP6 Chinese Name 棕榈酰化膜蛋白6抗体 Alias MAGUK p55 subfamily member 6 VELI associated MAGUK 1; MAGUK protein p55T; MPP6; Palmitoylated 6 MAGUK p55 subfamily member 6; PALS2; Protein associated with Lin7 2; VELI associated MAGUK 1; MPP6_HUMAN. Research Area Tumour Cell biology immunology Chromatin and nuclear signals Cyclin Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 61kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human VAM1/MPP6: 431-540/540 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Progression of cells from interphase to mitosis involves alterations in cell structures and activities. The transition from G2 to M phase is induced by M phase promoting factor, or MPF. In M phase, many proteins are phosphorylated directly by MPF or indirectly by kinases activated by MPF. These M phase phosphoproteins (MPPs, or MPHOSPHs) permit disassembly of interphase structures and generation of M phase enzymatic activities and structures. VAM1 or MPP6 is thought to be a nucleolus specific exosome co factor, required for its role in the maturation of 5.8S rRNA.
Subunit:
Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins.
Subcellular Location:
Membrane; Peripheral membrane protein (By similarity).
Tissue Specificity:
Abundant in testis, brain, and kidney with lower levels detectable in other tissues.
Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 2 L27 domains.
Contains 1 PDZ (DHR) domain.
Contains 1 SH3 domain.
SWISS:
Q9NZW5
Gene ID:
51678
Database links:Entrez Gene: 51678 Human
Entrez Gene: 56524 Mouse
Omim: 606959 Human
SwissProt: Q9NZW5 Human
SwissProt: Q9JLB0 Mouse
Unigene: 533355 Human
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