Product Name	FES
Chinese Name	原癌基因酪氨酸蛋白激酶FES抗体
Alias	c-fes/fps protein; cFES; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami; Feline sarcoma oncogene; FPS; Oncogene FES; Oncogene FES feline sarcoma virus; Proto oncogene tyrosine protein kinase Fes/Fps; proto-oncogene tyrosine-protein kinase Fes/Fps.
Research Area	Tumour  immunology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	93kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FES: 121-220/822
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex. SWISS: P07332 Gene ID: 2242 Database links: Entrez Gene: 507304 Cow Entrez Gene: 2242 Human Entrez Gene: 14159 Mouse Entrez Gene: 361597 Rat Omim: 190030 Human SwissProt: P07332 Human SwissProt: P16879 Mouse Unigene: 7636 Human Unigene: 48757 Mouse Unigene: 27239 Rat

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