Product Name	HOXA5
Chinese Name	同源异型盒基因HOXA5蛋白抗体
Alias	Homeo box 1C antibody Homeobox A5 antibody Homeobox protein HOXA5 antibody HOX 1 antibody HOX 1.3 antibody HOX 1C antibody HOX1 antibody HOX1.3 antibody HOX1C antibody; HXA5_HUMAN.
literatures	Specific References  (1)     |     SL5713R has been referenced in 1 publications. [IF=3.231] Dingshuang Chen. et al. Hoxa5 Inhibits the Proliferation and Induces Adipogenic Differentiation of Subcutaneous Preadipocytes in Goats. ANIMALS. 2022 Jan;12(14):1859  WB ;  Goat.   PubMed:35883405
Research Area	Tumour  immunology  Chromatin and nuclear signals  Cyclin  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29 kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HOXA5: 201-270/270
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. Subcellular Location: Nucleus. Similarity: Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: P20719 Gene ID: 3202 Database links: Entrez Gene: 3202 Human Entrez Gene: 15402 Mouse Entrez Gene: 79241 Rat Omim: 142952 Human SwissProt: P20719 Human SwissProt: P09021 Mouse SwissProt: P52949 Rat Unigene: 655218 Human Unigene: 173 Mouse Unigene: 8465 Rat p53基因保护细胞不会癌变，HOXA5协助细胞的p53保持适当水平。如果HOXA5水平下降或完全缺乏，p53基因就不能防止细胞癌变。低水平的HOXA5通过另一种促甲基化机制使基因不能表达而发生。正常状态下，p53Tumour抑制蛋白发现DNA的损伤，将信息传递给细胞以修复损伤或者导致死亡。过少或没有p53不仅减弱细胞正常功能，而且降低细胞感受损伤的能力。因此，若细胞缺少HOXA5蛋白也很可能是Tumour发展的重要过程。

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