Product Name	TUSC2
Chinese Name	血小板源性生长因子A相关蛋白2抗体
Alias	C3orf11; FUS1; Fusion 1 protein; PAP; PDAP2; PDGFA associated protein 2; Tumor suppressor candidate 2; TUSC 2; TUSC2_HUMAN.
Research Area	Tumour  immunology  Chromatin and nuclear signals  Signal transduction  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TUSC2: 31-100/110
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TUSC2/FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21.3 region where allele losses and genetic alterations occur early and frequently for many human cancers. Expression of TUSC2 protein is absent or reduced in the majority of lung cancers and premalignant lung lesions. Restoration of TUSC2 function in 3p21.3-deficient non-small cell lung carcinoma cells significantly inhibits tumor cell growth by induction of apoptosis and alteration of cell cycle kinetics. TUSC2 may induce apoptosis through the activation of the intrinsic mitochondrial-dependent and Apaf-1-associated pathways and inhibit the function of protein tyrosine kinases including EGFR, PDGFR, AKT, c-Abl, and c-Kit. Function: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. Tissue Specificity: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta. Post-translational modifications: Myristoylation is required for tumor suppressor activity. Similarity: Belongs to the TUSC2 family. SWISS: O75896 Gene ID: 11334 Database links: Entrez Gene: 11334 Human Entrez Gene: 80385 Mouse Entrez Gene: 448842 Pig Entrez Gene: 501052 Rat Omim: 607052 Human SwissProt: O75896 Human SwissProt: Q9WVF8 Mouse Unigene: 517981 Human Unigene: 21739 Mouse Unigene: 120731 Rat

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