Product Name	phospho-PTPN7 (Ser246)
Chinese Name	磷酸化非受体型蛋白酪氨酸磷酸酶7抗体
Alias	PTPN7(phospho S246); BPTP 4; BPTP4; Dual specificity phosphatase 1; Hematopoietic protein tyrosine phosphatase; LC PTP; LCPTP; LPTP; Protein tyrosine phoshatase non receptor type stress induced; Protein tyrosine phoshatase nonreceptor type stress induced; Protein tyrosine phosphatase LC PTP; Protein tyrosine phosphatase non receptor type 7; PTPN 7; PTPNI; Tyrosine protein phosphatase non receptor type 7; PTN7_HUMAN.
Product Type	Phosphorylated anti
Research Area	Tumour  immunology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human PTPN7 around the phosphorylation site of Ser246: CR(p-S)VK
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Function: Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Subunit: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed exclusively in thymus and spleen. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 tyrosine-protein phosphatase domain. SWISS: P35236 Gene ID: 5778 Database links: Entrez Gene: 5778 Human Entrez Gene: 320139 Mouse Entrez Gene: 246781 Rat Omim: 176889 Human SwissProt: P35236 Human SwissProt: Q8BUM3 Mouse SwissProt: P49445 Rat Unigene: 402773 Human Unigene: 258388 Mouse Unigene: 10160 Rat
Product Picture	Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti-phospho-PTPN7 (Ser246) (SL5557R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 48 kD

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