Product Name	phospho-PKMYT1 (Thr495)
Chinese Name	磷酸化蛋白激酶PKMYT1(Thr495)抗体
Alias	PKMYT1(phospho T495);cdc2 inhibitory kinase; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT 1; Pkmyt1; PMYT1_HUMAN; Protein kinase membrane associated tyrosine/threonine 1; Protein kinase Myt1; DKFZp547K1610; FLJ20093.
literatures	Specific References  (2)     |     SL5531R has been referenced in 2 publications. [IF=6.714] Xu,et al.Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline.(2018) Aging Cell. 17:.  WB ;  Mouse.   PubMed:29383825 [IF=3.82] Xu,et al.Adipocytes affect castration-resistant prostate cancer cells to develop the resistance to cytotoxic action of NK cells with alterations of PD-L1/NKG2D ligand levels in tumor cells.(2018) The Prostate. 78:353-364.  WB ;  Human.   PubMed:29330929
Product Type	Phosphorylated anti
Research Area	immunology  Signal transduction  Cyclin  transcriptional regulatory factor  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human PKMYT1 around the phosphorylation site of Thr495: ED(p-T)LD
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Subunit: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1. Subcellular Location: Endoplasmic reticulum membrane. Golgi apparatus membrane. Post-translational modifications: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. Contains 1 protein kinase domain. SWISS: Q99640 Gene ID: 9088 Database links: Entrez Gene: 9088 Human Entrez Gene: 268930 Mouse Entrez Gene: 287101 Rat Omim: 602474 Human SwissProt: Q99640 Human SwissProt: Q9ESG9 Mouse Unigene: 77783 Human Unigene: 182193 Mouse Unigene: 204349 Rat
Product Picture	Sample: Lane 1: MCF-7 (Human) Cell Lysate at 30 ug Lane 2: A431 (Human) Cell Lysate at 30 ug Lane 3: Molt-4 (Human) Cell Lysate at 30 ug Lane 4: K562 (Human) Cell Lysate at 30 ug Lane 5: U2os (Human) Cell Lysate at 30 ug Lane 6: U251 (Human) Cell Lysate at 30 ug Lane 7: A549 (Human) Cell Lysate at 30 ug Primary: Anti-phospho-PKMYT1 (Thr495) (SL5531R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD

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