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Product Name phospho-FXYD1 (Ser88) Chinese Name 磷酸化磷酸神经膜抗体 Alias FXYD1 (phospho S88); FXYD1 (phospho Ser88); p-FXYD1 (phospho S88); FXYD domain containing ion transport regulator 1; Phospholemman; PLM; fxyd1; PLM_HUMAN; FXYD domain-containing ion transport regulator 1. Product Type Phosphorylated anti Research Area Tumour immunology Neurobiology Channel protein The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Rat, Dog, Pig, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 10kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated Synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser88: RL(p-S)TR Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.
Function:
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Subcellular Location:
Membrane; single-pass type I membrane protein
Tissue Specificity:
Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.
Post-translational modifications:
Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK.
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.
Similarity:
Belongs to the FXYD family.
SWISS:
O00168
Gene ID:
5348
Database links:
Entrez Gene: 5348 Human
Entrez Gene: 56188 Mouse
Omim: 602359 Human
SwissProt: O00168 Human
SwissProt: Q9Z239 Mouse
Unigene: 442498 Human
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