Product Name	phospho-EIF4EBP1 (Ser100)
Chinese Name	磷酸化eIF4EBinding protein抗体
Alias	eIF4EBP1 (phospho S100); eIF4EBP1 (phospho Ser100); p-eIF4EBP1 (Ser100); eIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; 4EBP1; BP 1; BP1; eIF4E binding protein 1; eIF4E-binding protein 1; Eukaryotic translation initiation factor 4E binding protein 1; MGC4316; PHAS I; PHASI; PHAS-I; PHAS; 4E-BP1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; Phosphorylated heat and acid stable protein regulated by insulin 1; 4EBP1_HUMAN.
Product Type	Phosphorylated anti
Research Area	Tumour  immunology  Signal transduction  Apoptosis  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Mouse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from mouse 4EBP1 around the phosphorylation site of Ser100: PS(p-S)PE
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]. Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Subunit: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with RPTOR. Post-translational modifications: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Similarity: Belongs to the eIF4E-binding protein family. SWISS: Q13541 Gene ID: 1978 Database links: Entrez Gene: 1978 Human Entrez Gene: 13685 Mouse Entrez Gene: 116636 Rat Omim: 602223 Human SwissProt: Q13541 Human SwissProt: Q60876 Mouse SwissProt: Q62622 Rat Unigene: 411641 Human Unigene: 6700 Mouse Unigene: 11161 Rat 4E-BP1是一种分子量为10-12kDa 的酸性蛋白，与eIF4G 竞争结合。4E-BPs 对 eIF4E 的结合是可逆的，并依赖于 4E-BP 的磷酸化状态。非磷酸化的4E-BP1 能与 eiF4E 牢固结合，而磷酸化的4E-BP1则不能。 而一些蛋白激酶Akt、 TOR、 MAPK、S6激酶和Cdc2是已知的能通过对35、45、69位的苏氨酸残基或64位的丝氨酸残基进行磷酸化而使4E-BP1丧失对eIF4E结合能力的激酶。然而，并非所有的磷酸化事件都能同样地阻断4EBP1-eIF4E的相互作用。

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