Product Name	LLGL2
Chinese Name	相似Tumour抑制基因HUGL抗体
Alias	HGL; Human giant larvae homolog; L2GL2; L2GL2_HUMAN; Lethal 2 giant larvae protein homolog 2; Lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL2.
literatures	Specific References  (1)     |     SL4771R has been referenced in 1 publications. [IF=3.51] Forteza et al. Conditional knockout of polarity complex (atypical) PKCι reveals an anti-inflammatory function mediated by NF-κB. (2016) Mol.Biol.Cell. 27:2186-97  IF ;  Mouse.   PubMed:27226486
Research Area	Tumour  Cell biology  Signal transduction  Cyclin  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	112kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LLGL2: 601-700/1020
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. Subunit: Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis. Subcellular Location: Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells. Post-translational modifications: Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex. Similarity: Belongs to the WD repeat L(2)GL family. Contains 14 WD repeats. SWISS: Q6P1M3 Gene ID: 3993 Database links: Entrez Gene: 3993 Human Entrez Gene: 217325 Mouse Entrez Gene: 360661 Rat SwissProt: Q6P1M3 Human SwissProt: Q3TJ91 Mouse Unigene: 514477 Human Unigene: 290450 Mouse

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