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Product Name GRM2 Chinese Name 促代谢型谷氨酸受体2抗体 Alias Metabotropic Glutamate Receptor 2; Glutamate Receptor Metabotropic 2; Gprc1b; AMPA selective glutamate receptor 2; GLUR 2; GLUR2; GLURB; Glutamate receptor metabotropic 2; Metabotropic Glutamate Receptor 2; GPRC1B; GRM 2; mGlu 2; MGlu2; MGLUR 2; Mglur2; GRM2_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Chicken, Dog, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 96kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GRM2/GLUR2: 151-250/879 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Function:
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Subunit:
Interacts with GRASP (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed in different regions of the adult brain as well as in fetal brain.
Similarity:
Belongs to the G-protein coupled receptor 3 family.
SWISS:
Q14416
Gene ID:
2912
Database links:
Entrez Gene: 2912 Human
Entrez Gene: 108068 Mouse
Omim: 604099 Human
SwissProt: Q14416 Human
SwissProt: Q14BI2 Mouse
Unigene: 121510 Human
Unigene: 410822 Mouse
Unigene: 424639 Mouse
Unigene: 9681 Rat
谷氨酸受体-代谢能2;主要参与细胞Signal transduction及突触传递,在G protein-coupled receptor蛋白Signal transduction途径中有一定的作用,并且有负调控腺苷酸环化酶的作用,为膜性蛋白,在胞膜、胞浆中表达。Product Picture Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Cerebellum tissue lysates
Lane 3: Rat Cerebrum tissue lysates
Lane 4: Human SH-SY5Y cell lysates
Primary: Anti-GRM2 (SL4769R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 96 kD
Observed band size: 120 kD
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