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Product Name APOC3 Chinese Name 载LipoproteinC3抗体 Alias APO C3; Apo CIII; Apo-CIII; APOC 3; ApoC III; ApoC-III; APOC3; APOC3_HUMAN; ApoCIII; Apolipoprotein C III; Apolipoprotein C-III; Apolipoprotein C3; ApolipoproteinCIII; MGC150353. literatures Specific References (4) | SL4741R has been referenced in 4 publications.[IF=4.87] Lozhkin, Andrey, et al. "NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis." Journal of Molecular and Cellular Cardiology (2016). IHC-F ; Mouse.[IF=2.984] Yitong Pan. et al. N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats. Peerj. 2021 Aug;9:e11909 WB,IF ; Rat.[IF=2.136] Hou Z et al. Comparative proteomic identification buffalo spermatozoa during in vitro capacitation. (2018) Theriogenology 126:303-309. WB ; Buffalo.[IF=2.136] Hou Z et al. Comparative proteomic identification of capacitation and noncapacitation swamp buffalo spermatozoa. Theriogenology. 2019 Feb 7;128:176-183. WB ; buffalo.Research Area Tumour Cardiovascular Cell biology immunology Signal transduction Lipoprotein The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 9kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human APOC3: 21-80/99 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. It inhibits lipoprotein lipase and hepatic lipase and it is thought to delay catabolism of triglyceride-rich particles. An increase in apoC-III levels induces the development of hypertriglyceridemia.
Function:
Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular Location:
Secreted.
Tissue Specificity:
Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Post-translational modifications:
O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
DISEASE:
Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the apolipoprotein C3 family.
SWISS:
P02656
Gene ID:
345
Database links:Entrez Gene: 345 Human
Entrez Gene: 11814 Mouse
Omim: 107720 Human
SwissProt: P02656 Human
SwissProt: P33622 Mouse
Unigene: 73849 Human
Unigene: 390161 Mouse
Unigene: 195323 Rat
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