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Product Name MRC1, Alexa Fluor 750 conjugated Chinese Name AF750标记的巨噬细胞甘露糖受体 (CD206) 抗体 Alias Macrophage mannose receptor 1; Mannose Receptor; C-type lectin domain family 13 member D; CD206; CD 206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1. Research Area Cell biology immunology transcriptional regulatory factor The cell membrane受体 glycoprotein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, ) Applications IF=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 160kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MRC1/CD206: 201-300/1456 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq]
Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
Subcellular Location:
Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
Similarity:
Contains 8 C-type lectin domains.
Contains 1 fibronectin type-II domain.
Contains 1 ricin B-type lectin domain.
SWISS:
P22897
Gene ID:
4360
Database links:Entrez Gene: 4360 Human
Entrez Gene: 17533 Mouse
Omim: 153618 Human
SwissProt: P22897 Human
SwissProt: Q61830 Mouse
Unigene: 75182 Human
Unigene: 2019 Mouse
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