Product Name	ICAM1
Chinese Name	细胞间粘附分子-1（CD54）抗体
Alias	BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor.
literatures	Specific References  (11)     |     SL4617R has been referenced in 11 publications. [IF=6.691] Yu-Chen Chen. et al. Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy. 2021 Jul 13  WB,IHC ;  Human.   PubMed:34255241 [IF=4.522] Zhao H et al. miR‐181a/b‐5p ameliorates inflammatory response in monocrotaline‐induced pulmonary arterial hypertension by targeting endocan. J Cell Physiol. 2019 Oct 21.  WB ;  Rat.   PubMed:31637717 [IF=4.36] Xiao Li. et al. Mechanism by which Huoxue Tongluo Qiwei Decoction improves the erectile function of rats with diabetic erectile dysfunction. J Ethnopharmacol. 2022 Jan;283:114674  WB ;  Rat.   PubMed:10.1016/j.jep.2021.114674 [IF=3.905] Fen Xu. et al. Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway. Exp Cell Res. 2022 Mar;412:113025  IF ;  Rat.   PubMed:35026282 [IF=3.69] Ji-Sheng Wang. et al. Effect of leech-centipede medicine on improving erectile function in DIED rats via PKC signalling pathway-related molecules. J Ethnopharmacol. 2021 Mar;267:113463  WB ;  Rat.   PubMed:33049347 [IF=3.298] Zhongxiao Zhou. et al. Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats:. INT J IMMUNOPATH PH. 2022;():  WB ;  Rat.   PubMed:35731855 [IF=2.976] Peng Y et al. Sonodynamic therapy improves anti‑tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft. Oncol Rep. 2018 Oct;40(4):2163-2170.   IHF ;  Mouse.   PubMed:30106435 [IF=2.17] Wang, Xiaoyu, et al. "Preliminary research of relationship between acute peritonitis and celiac primo vessels." Evidence-Based Complementary and Alternative Medicine 2013 (2013).  IHC-P ;  Rat.   PubMed:24069050 [IF=2.11] Kim et al. Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model. (2015) Mol.Vi. 21:1210-23  WB ;  Mouse.   PubMed:26604661 [IF=1.26] Zhou et al. Ultrasound combined with targeted cationic microbubble-mediated angiogenesis gene transfection improves ischemic heart function. (2017) Exp.Ther.Me. 13:2293-2303  WB ;  Human.   PubMed:28565841 [IF=0.181] Li S et al. The Effect of YiQiFuMai on Ischemic Heart Failure by Improve Myocardial Microcirculation and Increase eNOS and VEGF Expression. International Journal of Clinical Medicine,2020 11, 84-100.  WB ;  Rabbit.   PubMed:doi: 10.4236/ijcm.2020.112009
Research Area	Tumour  immunology  Signal transduction  Stem cells  The cell membrane受体  Cell adhesion molecule  Cell Surface Molecule  glycoprotein  Cell type markers  lymphocyte  t-lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ICAM-1: 180-250/532 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]. Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Subunit: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Subcellular Location: Membrane; Single-pass type I membrane protein. Post-translational modifications: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. Similarity: Belongs to the immunoglobulin superfamily. ICAM family. ontains 5 Ig-like C2-type (immunoglobulin-like) domains. SWISS: P05362 Gene ID: 3383 Database links: Entrez Gene: 3383 Human Entrez Gene: 15894 Mouse Entrez Gene: 25464 Rat Omim: 147840 Human Unigene: 643447 Human SwissProt: P05362 Human SwissProt: P13597 Mouse SwissProt: Q00238 Rat Unigene: 435508 Mouse Unigene: 12 Rat
Product Picture	Sample: A549 Cell (Human) Lysate at 40 ug Primary: Anti-ICAM1 (SL4617R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD Sample: Raw264.7 cell (Mouse) Lysate at 40 ug Raji Cell (Human) Lysate at 40 ug Heart (Mouse) Lysate at 40 ug Thymus (Mouse) Lysate at 40 ug Primary: Anti-ICAM1 (SL4617R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD Blank control(blue): U937(fixed with 2% paraformaldehyde (10 min)) Primary Antibody: Rabbit Anti-ICAM1 antibody(SL4617R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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