Product Name	NDV HN
Chinese Name	鸡新城疫血凝素－神经氨酸酶抗体
Alias	hemagglutinin-neuraminidase; newcastle disease virus(NDV); HN; hemagglutinin-neuraminidase protein [Newcastle disease virus]; HN_NDVB; Newcastle disease virus HN; Newcastle disease virus hemagglutinin neuraminidase.
literatures	Specific References  (2)     |     SL4529R has been referenced in 2 publications. [IF=4.43] Wei, Ding, et al. "Oncolytic Newcastle disease virus expressing chimeric antibody enhanced anti-tumor efficacy in orthotopic hepatoma-bearing mice."Journal of Experimental & Clinical Cancer Research 34.1 (2015): 1.  IHC-P ;  Mouse.   PubMed:26689432 [IF=3.24] Bo-Kyoung Jung. et al. The human ACE-2 receptor binding domain of SARS-CoV-2 express on the viral surface of the Newcastle disease virus as a non-replicating viral vector vaccine candidate. Plos One. 2022 Feb;17(2):e0263684  WB ;  Monkey.   PubMed:35134091
Research Area	immunology  Bacteria and viruses
Immunogen Species	Rabbit
Clonality	Polyclonal
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from NDV HN protein: 401-500/577/577
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The entry of Newcastle disease virus (NDV), a prototype paramyxovirus, is directed by two virion glycoproteins, the hemagglutinin-neuraminidase (HN) protein and the fusion (F) protein . HN protein, the virus attachment protein, binds to sialic acid-containing receptors, and F protein mediates membrane fusion. In contrast to many viral fusion proteins, paramyxovirus F proteins do not require the acid pH of endosomes to activate fusion activity. As a consequence, infected cells expressing both attachment proteins and F proteins can fuse with adjacent cells to form multinuclear cells, or syncytia, a process that is assumed to mimic virus-cell fusion . Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity). Subcellular Location: Virion membrane; Single-pass type II membrane protein (Potential). Host cell membrane; Single-pass type II membrane protein (Potential). Similarity: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. SWISS: P32884 Gene ID: N/A Database links: SwissProt: P32884 NDV
Product Picture	Sample: Lane 1: Recombinant NDV HN protein, His Primary: Anti-NDV HN (SL4529R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kDa Observed band size: 61 kDa

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