Product Name	NUP188
Chinese Name	核孔蛋白188抗体
Alias	BC025526; FLJ21639; hNup188; KIAA0169; mKIAA0169; Nucleoporin 188kDa; Nucleoporin NUP188 homolog; OTTMUSP00000018197; RP11-167N5.2; RP23-395P6.3; U89435.
Research Area	Cell biology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	196kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NUP188: 671-770/1749
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013] Function: May function as a component of the nuclear pore complex (NPC). Subcellular Location: Nucleus, nuclear pore complex. DISEASE: Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning. SWISS: Q5SRE5 Gene ID: 23511 Database links: Entrez Gene: 23511 Human Entrez Gene: 227699 Mouse Entrez Gene: 366016 Rat Omim: 615587 Human SwissProt: Q5SRE5 Human SwissProt: Q6ZQH8 Mouse Unigene: 308340 Human Unigene: 330119 Mouse Unigene: 11918 Rat

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