Product Name	Defensin beta 2
Chinese Name	防御素β2抗体
Alias	beta Defensin 2; beta-defensin 2; mBD-2; Defensin, beta 2; Defb2; MGC129140; MGC129141; Skin-antimicrobial peptide 1; SAP1; BD-2; BD 2; BD2; Beta 4 Defensin; DEF B2; DEF B4; DEFB 102; DEFB 2; DEFB-2; DEFB 4; DEFB102; DEFB2; DEFB4; Defensin 4 beta; Defensin beta 4; HBD-2; HBD 2; HBD2; SAP 1; SAP1; Skin antimicrobial peptide 1; DFB4A_HUMAN; DFB4A_RAT; DEFB4A.
literatures	Specific References  (3)     |     SL4307R has been referenced in 3 publications. [IF=4.494] Nur Atalay. et al. Serum, saliva, and gingival tissue human β-defensin levels in relation to retinoic acid use. J PERIODONTOL. 2022 Nov;:  IHC ;  Human.   PubMed:36440958 [IF=2.38] Al‐Samadi, Ahmed, et al. "Increased beta 2 defensin in recurrent aphthous ulcer." Oral Diseases (2014).  IHC-P ;  Human.   PubMed:24854020 [IF=0] Shi et al. Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis. (2014) Oncotarget. 5:11333-44  IHC ;  Rat.   PubMed:25226614
Research Area	Cell biology  Developmental biology  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human beta 2 Defensin: 24-64/64
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Beta-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. Human b-defensin 2 is locally regulated by inflammation and is the first member of the b-defensin family that is locally inducible by inflammation. The murine homolog of human b-defensin 2, which is called b-defensin 3, is present in the respiratory system and in low levels in the epithelial cells of the intestine and lung. The unique murine b-defensin 2 (Defb2) is not expressed in airways of untreated mice, but is upregulated in the airways by lipopolysaccharide and may contribute to host defense at the mucosal surface of the airways Function: Has antibacterial activity. Subcellular Location: Secreted. Tissue Specificity: Expressed in the skin and respiratory tract. Similarity: Belongs to the beta-defensin family. LAP/TAP subfamily. SWISS: O15263 Gene ID: 1673 Database links: Entrez Gene: 100289462 Human Entrez Gene: 1673 Human Omim: 602215 Human SwissProt: O15263 Human Unigene: 105924 Human Unigene: 721744 Human

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