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Product Name Defensin beta 2 Chinese Name 防御素β2抗体 Alias beta Defensin 2; beta-defensin 2; mBD-2; Defensin, beta 2; Defb2; MGC129140; MGC129141; Skin-antimicrobial peptide 1; SAP1; BD-2; BD 2; BD2; Beta 4 Defensin; DEF B2; DEF B4; DEFB 102; DEFB 2; DEFB-2; DEFB 4; DEFB102; DEFB2; DEFB4; Defensin 4 beta; Defensin beta 4; HBD-2; HBD 2; HBD2; SAP 1; SAP1; Skin antimicrobial peptide 1; DFB4A_HUMAN; DFB4A_RAT; DEFB4A. literatures Specific References (3) | SL4307R has been referenced in 3 publications.[IF=4.494] Nur Atalay. et al. Serum, saliva, and gingival tissue human β-defensin levels in relation to retinoic acid use. J PERIODONTOL. 2022 Nov;: IHC ; Human.[IF=2.38] Al‐Samadi, Ahmed, et al. "Increased beta 2 defensin in recurrent aphthous ulcer." Oral Diseases (2014). IHC-P ; Human.[IF=0] Shi et al. Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis. (2014) Oncotarget. 5:11333-44 IHC ; Rat.Research Area Cell biology Developmental biology The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 4kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human beta 2 Defensin: 24-64/64 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Beta-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. Human b-defensin 2 is locally regulated by inflammation and is the first member of the b-defensin family that is locally inducible by inflammation. The murine homolog of human b-defensin 2, which is called b-defensin 3, is present in the respiratory system and in low levels in the epithelial cells of the intestine and lung. The unique murine b-defensin 2 (Defb2) is not expressed in airways of untreated mice, but is upregulated in the airways by lipopolysaccharide and may contribute to host defense at the mucosal surface of the airways
Function:
Has antibacterial activity.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in the skin and respiratory tract.
Similarity:
Belongs to the beta-defensin family. LAP/TAP subfamily.
SWISS:
O15263
Gene ID:
1673
Database links:Entrez Gene: 100289462 Human
Entrez Gene: 1673 Human
Omim: 602215 Human
SwissProt: O15263 Human
Unigene: 105924 Human
Unigene: 721744 Human
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