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Product Name CNTROB Chinese Name 乳腺癌易感基因2相互作用蛋白抗体 Alias Centrobin; centrobin, centrosomal BRCA2 interacting protein; Centrosomal BRCA2 interacting protein; LIP8; LYST interacting protein 8; CNTRB_HUMAN. Research Area Tumour Cell biology immunology Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 101kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CNTROB: 51-150/903 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CNTROB is a centrosomal protein that interacts with BRCA2 and is required for centriole duplication with inhibition of centriole duplication leading to defects in cytokinesis.
Function:
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
Subunit:
Interacts with LYST.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole.
Tissue Specificity:
Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
SWISS:
Q8N137
Gene ID:
116840
Database links:Entrez Gene: 116840 Human
Omim: 611425 Human
SwissProt: Q8N137 Human
Unigene: 348012 Human
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