Product Name	CLIP170
Chinese Name	细胞质连接蛋白1抗体
Alias	CAP GLY domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CLIP 170; CLIP; CLIP-170; CLIP1; CLIP-1; CLIP 1; CLIP1_HUMAN; CYLN1; cytoplasmic linker 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha 2; Cytoplasmic linker protein 170 alpha-2; Reed Steinberg cell expressed intermediate filament associated; Reed Sternberg intermediate filament associated protein 3; Reed-Sternberg intermediate filament-associated protein; Restin; RSN.
Research Area	Tumour  Cell biology  immunology  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	158kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLIP1/CLIP170: 451-550/1438
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules. Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Subunit: Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles. Tissue Specificity: Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. Post-translational modifications: Phosphorylated. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules. Similarity: Contains 2 CAP-Gly domains. Contains 1 CCHC-type zinc finger. SWISS: P30622 Gene ID: 6249 Database links: Entrez Gene: 6249 Human Entrez Gene: 56430 Mouse Entrez Gene: 65201 Rat Omim: 179838 Human SwissProt: P30622 Human SwissProt: Q922J3 Mouse Unigene: 524809 Human Unigene: 241109 Mouse Unigene: 441802 Mouse Unigene: 22069 Rat

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