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Product Name BPI Chinese Name 杀菌/通透性增强蛋白抗体 Alias Neutrophil Bactericidal Protein BP30; Bactericidal permeability-increasing protein; Bactericidal/permeability increasing protein; BPI_HUMAN; CAP 57; CAP-57; BPI fold containing family D, member 1; BPIFD1. Research Area Cell biology immunology Apoptosis Bacteria and viruses t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 50kDa Cellular localization cytoplasmic The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human BPI: 141-240/487 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subunit:
Monomer. Homodimer; disulfide-linked.
Subcellular Location:
Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue Specificity:
Restricted to cells of the myeloid series.
Similarity:
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
SWISS:
P17213
Gene ID:
671
Database links:Entrez Gene: 671 Human
Omim: 109195 Human
SwissProt: P17213 Human
Unigene: 529019 Human
杀菌/通透性增加蛋白(Bactericidal/permeability-increasing protein,BPI)是哺乳动物中性粒细胞中存在的一种碱性蛋白,BPI能与革兰氏阴性菌脂多糖结合,增加外膜对抗菌药物的通透性,具有中和内毒素和杀灭细菌的生物学作用,在革兰氏阴性菌感染的治疗方面有良好的发展前景。
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